Pharmacokinetics of ammonium sulfate gradient loaded liposome–encapsulated oxymorphone and hydromorphone in healthy dogs
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Preparation of Cefquinome Sulfate Proliposome and its Pharmacokinetics in Rabbit
Cefquinome Sulfate (CS) is a fourth-generation cephalosporin, which has been developed solely for veterinary use. It shows potent antibacterial activity against a broad spectrum of bacterial species. However, Cefquinome is susceptible to hydrolysis, which limiting its clinical employment efficacies to some extent. So, in this study, to increase Cefquinome Sulfate biological half-life, a novel C...
متن کاملPreparation of Cefquinome Sulfate Proliposome and its Pharmacokinetics in Rabbit
Cefquinome Sulfate (CS) is a fourth-generation cephalosporin, which has been developed solely for veterinary use. It shows potent antibacterial activity against a broad spectrum of bacterial species. However, Cefquinome is susceptible to hydrolysis, which limiting its clinical employment efficacies to some extent. So, in this study, to increase Cefquinome Sulfate biological half-life, a novel C...
متن کاملPharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers.
UNLABELLED We evaluated pharmacokinetics and absolute bioavailability of single doses of hydromorphone hydrochloride after administration of 1.0 and 2.0 mg of intranasal (IN) and 2.0 mg of IV hydromorphone hydrochloride. An open-label, randomized, three-way crossover study was conducted in 24 healthy volunteers (13 men and 11 women). IN doses were delivered as 0.1-mL metered-dose sprays into on...
متن کاملGC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine.
A procedure for the simultaneous confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine specimens by gas chromatography-mass spectrometry (GC-MS) is described. After the addition of nalorphine and naltrexone as the two internal standards, the urine is hydrolyzed overnight with beta-glucuronidase from E. coli. The urine is adjusted to...
متن کاملThe intravenous pharmacokinetics of diminazene in healthy dogs.
Diminazene remains one of South Africa's most commonly used antiprotozoal agents for the management of babesiosis in dogs. Although the drug has been on the market for over 40 years, its intravenous pharmacokinetics are poorly known. To better understand the pharmacokinetics of the drug Berenil, it was reconstituted in sterile water and administered intravenously to 6 adult German shepherd dogs...
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ژورنال
عنوان ژورنال: Veterinary Anaesthesia and Analgesia
سال: 2013
ISSN: 1467-2987
DOI: 10.1111/vaa.12042